Direct Meds vs MyStart Health: Price, Yearly Cost & Cancellation
On the most flexible semaglutide plans, Direct Meds costs $24 less over a year ($3,564 vs $3,588). On the most flexible tirzepatide plans, MyStart Health costs $1,200 less over a year ($3,588 vs $4,788). Direct Meds charges no membership fee; MyStart Health charges no membership fee. Prices verified September 24, 2026.
Side by side
| Direct Meds | MyStart Health | |
|---|---|---|
| Semaglutide, most flexible plan | $297/mo (90-day supply, 3-month commitment) | $299/mo |
| Tirzepatide, most flexible plan | $399/mo (90-day supply, 3-month commitment) | $299/mo |
| Semaglutide, lowest rate | $249/mo (not stated) | $299/mo (monthly (4-week supply) or 3-month (12-week supply) plan) |
| Tirzepatide, lowest rate | $399/mo (90-day supply, 3-month commitment) | $299/mo (monthly (4-week supply) or 3-month (12-week supply) plan) |
| Semaglutide, first year | $3,564 | $3,588 |
| Tirzepatide, first year | $4,788 | $3,588 |
| Membership fee | None | None |
| Higher doses | Not stated. | None per FAQ price-lock ('will never increase from your base plan amount, EVEN if your dosage increases'); first-time discount excluded. |
| Consultation | Async online intake/quiz reviewed by a licensed provider (FAQ: no appointments needed). | Online intake quiz reviewed by a licensed clinician; video consult or prescription within 24 hours, same-day video available. Unlimited clinician messaging at no added cost; refill intake form required every 3 months. |
| States | Not published | All 50 states |
| How to cancel | Turn off auto-refill in the account portal at least 48 hours before the next processing date (terms), or email help@direct-meds.com / call (888) 696-7176 (product pages). | Email support with 'CANCEL' in the subject line, or call 888-828-5816 (Mon-Fri 9am-7pm, Sat 10am-4pm ET). |
| Refunds | Orders can be cancelled within 24 hours if not yet with the provider network; after that generally not. No refunds for medication already received. Full refund if the doctor declines treatment. Advance notice 5-7 days before each charge. | Full refund if not medically eligible or if canceled before the pharmacy processes and ships the order. No refunds once shipped or once a prescription is written, and none for completed or partially completed membership periods; medication cannot be returned. |
| Trustpilot | 4.6 (15,693 reviews) | 4.1 (326 reviews) |
| Regulatory notes | FDA warning letter dated Sept 9, 2025 (posted Sept 16, 2025) to directmeds.com, Inc | FDA warning letter to MyStart Health LLC (Sept 9, 2025) for false or misleading claims about compounded semaglutide, including 'Generic brand-name semaglutide' wording that implied equivalence to FDA-approved drugs. |
First-year cost uses each provider's most flexible plan (month-to-month where offered), including any intro month and membership fee. Prepaid plans cost less per month but are harder to exit.
Choose Direct Meds if…
- you want the lower yearly cost for semaglutide ($3,564 vs $3,588 on their most flexible plans)
- you're willing to prepay for the lowest semaglutide rate ($249/mo on its not stated plan)
- a higher Trustpilot score matters to you (4.6 vs 4.1)
Choose MyStart Health if…
- you want the lower yearly cost for tirzepatide ($3,588 vs $4,788 on their most flexible plans)
- you're willing to prepay for the lowest tirzepatide rate ($299/mo on its monthly (4-week supply) or 3-month (12-week supply) plan plan)
- you need coverage in every state
Full reviews
Other comparisons
FAQ
Is Direct Meds or MyStart Health cheaper for semaglutide?
Direct Meds is cheaper on its most flexible plan: $3,564 for the first year vs $3,588, based on prices verified September 24, 2026.
Is Direct Meds or MyStart Health cheaper for tirzepatide?
MyStart Health is cheaper on its most flexible plan: $3,588 for the first year vs $4,788, based on prices verified September 24, 2026.
Do Direct Meds or MyStart Health charge a membership fee?
Direct Meds: None. MyStart Health: None.
Which has better reviews, Direct Meds or MyStart Health?
On Trustpilot, Direct Meds has 4.6 (15,693 reviews) and MyStart Health has 4.1 (326 reviews).
Sources
- Direct Meds: Homepage
- Direct Meds: Weight-loss page + FAQ
- Direct Meds: Semaglutide injection product page
- MyStart Health: Homepage FAQ (price, cancellation, price-lock)
- MyStart Health: Support FAQs
- MyStart Health: Refund policy
- Full source lists: Direct Meds, MyStart Health
Compounded medications are not FDA-approved finished drug products. This page is not medical advice.